- Incorporated in January 1881 to build from Denver to the Texas border, where it would connect with the Fort Worth and Denver City (FW&DC) Railroad building north from Fort Worth.
- Construction started in Mar 1881, reached Pueblo on 29 Apr 1882 with service starting on 11 May 1881, and constructed from Manitou Junction? to Colorado Springs? by 1 Dec 1882.
- Reorganized as the Denver, Texas & Fort Worth Railroad on 16 Mar 1886.
- Construction to close the Pueblo to Quanah, TX, gap started in early 1887, and was completed on 14 Mar 1888.
- The DT&FW was consolidated with other Union Pacific-controlled properties as the Union Pacific, Denver & Gulf Railway on 18 Mar 1890. It operated under UP control as a feeder system for the Union Pacific? transcontinental line until UP entered bankruptcy on 13 Oct 1893. The FW&DC remained a separate company, although also under UP influence.
- The UPD&G was reorganized as the Colorado & Southern Railway free of Union Pacific? control on 20 Dec 1898.
- The Fort Worth and Denver City (FW&DC) Railroad became the Fort Worth & Denver Railway on 7 Aug 1951, and was merged with the rest of the Colorado & Southern on 13 Jun 1952.
- The C&S? signed an agreement with the Santa Fe to use their track between Pueblo and Denver? in 189?. Most traffic was diverted to the SF mainline.
- Service on the line south of the connection with the Rock Island? at Falcon, CO? ceased in 1904. The entire route from Denver to Pueblo was abandoned and removed 1935-1936, except for the far northern end of the line to about Evans & Monaco in Denver. This final section was removed in the mid-2000s with the widening of I-25.